Volume 36, Issue 2 (7-2012)
Research in Medicine 2012, 36(2): 76-81 |
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Shahzadi S, Azimi P, Bitaraf M A, Azar M, Alikani M, Zali A, et al . Graded prognostic assessment scale to predict overall survival in patients diagnosed with brain metastases undergoing Gamma-knife radiosurgery. Research in Medicine 2012; 36 (2) :76-81
URL: http://pejouhesh.sbmu.ac.ir/article-1-1037-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-1037-en.html
Sohrab Shahzadi 
, Parisa Azimi , Mohammad Ali Bitaraf , Maziar Azar , Mazdak Alikani , Alireza Zali , Sohrab Sadeghi , Soraya Salmanian
, Parisa Azimi , Mohammad Ali Bitaraf , Maziar Azar , Mazdak Alikani , Alireza Zali , Sohrab Sadeghi , Soraya Salmanian
Department of Neurosurgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran , Parisa.azimi@gmail.com
Abstract: (9402 Views)
Abstract
Background: This study was done to define the role of Graded Prognostic Assessment (GPA) score for predicting overall survival in patients diagnosed with brain metastases undergoing Gamma-knife radiosurgery.
Materials and methods: Patients diagnosed with brain metastases who were candidates for Gamma-knife radiosurgery entered this cross sectional study between 2003 and 2011. Clinical and radiological parameters were evaluated, and the GPA score were determined. Kaplan–Meier, log-rank, was used to assess prognostic value of the GPA score.
Results: Two hundred and twenty patients were eligible to enter the study during the course of the study. Patients were aged 54 ± 12.7 years (19 to 82 years) and were followed for an average of 7 (range 1-25) months after treatment with Gamma-knife. Median survival times according to GPA were: GPA 0–1=4±0.4 months GPA 1.5–2.5=6±0.7 months GPA 3= 9±0.9 months and GPA 3.5–4.0= 12±1.8 months Mean overall survival was 7±0.6 months. The level of statistical significance between GPA groups was p < 0.0001.
Conclusion: It seems that the preoperative GPA is able to predict Gamma-knife radiosurgery results in patients with brain metastases. The results will need to be confirmed with further Clinical trials.
Keywords: Brain metastases, GPA Score, Gamma-knife radiosurgery, prognosis.
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