Volume 39, Issue 4 (2-2016)                   Research in Medicine 2016, 39(4): 163-168 | Back to browse issues page

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Kazemi F, Ebrahim K, Zahedi Asl S. Effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats . Research in Medicine. 2016; 39 (4) :163-168
URL: http://pejouhesh.sbmu.ac.ir/article-1-1575-en.html
School of Physical Education and Sport Sciences, Shahid Beheshti University , kazemi.fahimeh@yahoo.de
Abstract:   (4847 Views)

Background: Recently the role of apelin in improvement of dislipidemia has been known. The purpose of this study was to determine the effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats.

Methods: Twenty eight diabetic male Wistar rats were divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by injection of nicotinamide and streptozotocin. The aerobic training program included 8-week running on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the period of training, plasma level of apelin and lipids (TC, HDL-C, LDL-C, VLDL-C, TG and FFA) were measured. One-way analysis of variance (ANOVA) was used for analyzing data and P<0.05 was considered to be statistically significant.

Results: In trained diabetic compared with control diabetic group, a significant increase in apelin, a significant decrease in plasma level of LDL-C, VLDL-C and TG, an insignificant decrease in TC and FFA, insignificant increase in HDL-C were observed.

Conclusion: Results of present study showed that increase in plasma level of apelin following regular exercise by inhibition of lipolysis and decrease of blood lipids can improve dyslipidemia of type 2 diabetic rats.

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Type of Study: Original |
Received: 2015/03/31 | Accepted: 2016/03/7 | Published: 2016/03/13

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