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Backgrond: Primary dysmenorrhea is one of the most common gynecological complaints and problems considered in young girls. Scientific findings suggest that exercise and physical activity positively affects the problem. Thus, the purpose of this study was to compare the effect of 8 weeks high intensity interval and continuous moderate trainings on pain reduction, IL-6 and TNF-α blood levels in femals with primary dysmenorrhea. Materials and Methods: Thirty females (Mean±SD: height: 162.5 cm, weight: 60.5 kg, age: 18.5 year) were participated in this study. All subjects were randomly divided in to 3 groups: interval, continuous and control. 24 hours before starting training intervention, blood samples were taken to determine blood levels of IL-6, TNF-α, and VAS questionnaire completed for examining the pain reduction. Then, experimental groups trained for 8 weeks, 3 sessions per week. But control group did not perform any training program. Using analyzes of variance (ANOVA) data were analyzed. Findings: A significant reduction was observed in pain rate in both training groups, as pain more reduced in continuous moderate training group compared to high interval group (p˂0.05). In addition, no significant difference was observed between the rates of IL-6, TNF-α from pretest to posttest in all 3 groups (p˃0.05). Conclusion: It is can be recommended to female with using interval training, specially continuous average training can reduce own menstrual pain. However, further research is needed to identify possible mechanisms for reducing pain and inflammation in primary pysmenorrhea. .
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