Research in Medicine

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Background: Giardia lamblia is a common intestinal parasite associated with social or personal problems. With respect to the controversies regarding the efficacy and side effects of Metronidazole, Furazolidone and Paramomycine, the present study was conducted on adults infected by Giardia lamblia. Material and methods: 210 individuals infected with giardia lamblia were assigned in 3 groups. They were 15-45 years old. Patients were surveyed one and four weeks following the therapy with Metronidazole, Furazolidone and Paromomycine. Results were compared using chi square method. Results: Of 210 infected patients, 53.3% were urban residents, 44.6% were males and 51.4% were females. Infection was more commonly found in illiterates (46.7%), whereas it was less commonly observed in educated subjects (6.7%). Diarrhea was the most prevalent clinical sign (89.5%). Four weeks after the therapy, the efficacy of Metronidazole, Furazolidone and Paromomycine were 90, 81.4, 64.3%, respectively. Metallic taste (17.2%), darking of urine (18.6%) and tenesmus were the most frequent side effects of Metronidazole, Furazolidone and Paromomycine, respectively. Conclusion: With respect to the varied efficacy of antihelmentic drugs in the treatment of Giardiasis, further studies in different part of the country are highly recommended.

Keywords: Giardiasis, treatment, Drug side effects.

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