Volume 43, Issue 1 (9-2019)
Research in Medicine 2019, 43(1): 8-14 |
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afsordeh K, ranjbar R, alizadeh A. Effect of aerobic training and vitamin D supplements on fatty liver and lipid profiles in women with fatty liver. Research in Medicine 2019; 43 (1) :8-14
URL: http://pejouhesh.sbmu.ac.ir/article-1-1905-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-1905-en.html
Shahid Chamran University of Ahvaz, Ahvaz, Iran , ranjbar.ranjbar9@gmail.com
Abstract: (10952 Views)
Backgrond:Fatty liver, which impairs the balance of blood lipids, is one of the most common liver diseases
in the present century. The purpose of the present study was to investigate the effect of aerobic exercise and
vitamin D supplementation on fatty liver and lipid profiles.
Materials and Methods: In this semi-experimental study, conducted in the winter of 1395 in the city of Dehloran,
40 women (weight: 81.5±8.8 and BMI: ≥30) who had Fatty Liver, grades I to III, were randomly divided into
aerobic exercise and vitamin D supplement (combined), aerobic training, Vitamin D Supplementation, and
control groups (n=10). The exercise groups performed 45 minutes of exercise on treadmill with 60% maximum
heart rate for 8 weeks and 3 sessions per week. Supplementary groups received 50,000 units of vitamin D every
week. Blood samples were used to measure lipid profiles and liver enzymes and ultrasound to measure liver
parenchyma in pretest and posttest (48 hours after the latest session of aerobic training). Descriptive statistics
were used to determine the mean and standard deviation of each variable and Shapiro-Wilkes test to determine
the natural distribution of data. Also, covariance analysis was used to examine the changes between groups.
In order to compare the two groups, Bonferron’s post hoc test was used.
Results: The hepatic enzymes in the combined group and the aerobic training group were significantly
different compared with the control and vitamin D supplementation groups (p<0.05) (ALP=0/001, ALT=0/014,
AST=0/000. However, it was not found to be statistically different between combined and aerobic training in
the hepatic enzymes. The liver parenchyma was significantly decreased in the combined group compared
with other groups (p<0.05) (P=0/000). In addition, Triglyceride and LDL levels decreased significantly in
the combined group as compared with other groups (p<0.05) (LDL=0/011, TG=0/015). However, there was
no statistically significant difference in the HDL and cholesterol between the groups (p>0.05) (HDL= 0/148,
COLE=0/591).
Conclusion: Vitamin D supplementation with aerobic exercise can have more effects on the levels of liver
enzymes, liver parenchyma, as well as triglyceride and LDL in women with fatty liver.
Keywords: Aerobic exercise; Vitamin D; Fatty liver; Liver enzymes; Lipid pr ofiles
in the present century. The purpose of the present study was to investigate the effect of aerobic exercise and
vitamin D supplementation on fatty liver and lipid profiles.
Materials and Methods: In this semi-experimental study, conducted in the winter of 1395 in the city of Dehloran,
40 women (weight: 81.5±8.8 and BMI: ≥30) who had Fatty Liver, grades I to III, were randomly divided into
aerobic exercise and vitamin D supplement (combined), aerobic training, Vitamin D Supplementation, and
control groups (n=10). The exercise groups performed 45 minutes of exercise on treadmill with 60% maximum
heart rate for 8 weeks and 3 sessions per week. Supplementary groups received 50,000 units of vitamin D every
week. Blood samples were used to measure lipid profiles and liver enzymes and ultrasound to measure liver
parenchyma in pretest and posttest (48 hours after the latest session of aerobic training). Descriptive statistics
were used to determine the mean and standard deviation of each variable and Shapiro-Wilkes test to determine
the natural distribution of data. Also, covariance analysis was used to examine the changes between groups.
In order to compare the two groups, Bonferron’s post hoc test was used.
Results: The hepatic enzymes in the combined group and the aerobic training group were significantly
different compared with the control and vitamin D supplementation groups (p<0.05) (ALP=0/001, ALT=0/014,
AST=0/000. However, it was not found to be statistically different between combined and aerobic training in
the hepatic enzymes. The liver parenchyma was significantly decreased in the combined group compared
with other groups (p<0.05) (P=0/000). In addition, Triglyceride and LDL levels decreased significantly in
the combined group as compared with other groups (p<0.05) (LDL=0/011, TG=0/015). However, there was
no statistically significant difference in the HDL and cholesterol between the groups (p>0.05) (HDL= 0/148,
COLE=0/591).
Conclusion: Vitamin D supplementation with aerobic exercise can have more effects on the levels of liver
enzymes, liver parenchyma, as well as triglyceride and LDL in women with fatty liver.
Keywords: Aerobic exercise; Vitamin D; Fatty liver; Liver enzymes; Lipid pr ofiles
Type of Study: Original |
Received: 2018/07/23 | Accepted: 2018/12/23 | Published: 2019/04/20
Received: 2018/07/23 | Accepted: 2018/12/23 | Published: 2019/04/20
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