Volume 13, Issue 1 And 2 (September 1989)
Research in Medicine 1989, 13(1 And 2): 43-54 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Azizi F. Altered Receptors. Research in Medicine 1989; 13 (1 and 2) :43-54
URL: http://pejouhesh.sbmu.ac.ir/article-1-2480-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-2480-en.html
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract: (3148 Views)
Receptor disorders may produce specific clinical manifestations resembling hypo-or hyper-function of related endocrine gland. Receptor disorders can be divided into five categories: 1)Altered receptor concentration exists in insulin resistance seen in obsity, familial hypercholesterolemia and in testicular feminization. 2) Altered receptor affinity can be seen in fasted obese patients, acromegaly and insulinoma. 3) Anti-receptor antibodies play an important role in the pathogenesis of Graves' disease, myasthenia gravis and insuline resistance. 4) Specificity spillover, where receptors of one hormone are stimulated by the excess amount of another hormone, is seen in galactorrhea due to acromegaly, hyperthyroidism due to trophorcastic tumors, and in hypoglycemia accompanied non-islet cell tumors. 5) Abnormal receptor-effector coupling is recognized in pseudohypoparathyroidism due to deficiency of the nucleotide regulatory protein involved in adenylate cyclase activation.
Type of Study: Original |
Subject:
Interdisciplinary (Educational Management, Educational research, Statistics, Medical education
Received: 1988/04/30 | Accepted: 1988/11/3 | Published: 1989/04/27
Received: 1988/04/30 | Accepted: 1988/11/3 | Published: 1989/04/27
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This Journal is licensed under a Creative Commons Attribution 4.0 International License | Research in Medicine
Designed & Developed by : Yektaweb