Research in Medicine

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sedighi M, bashiri J, nourazar A, hadi H. Effect of endurance training and olive oil supplementation on CD22 and TLR4 factors in obese male ratsy. Research in Medicine 2021; 45 (3) :31-37
URL: http://pejouhesh.sbmu.ac.ir/article-1-2573-en.html

Background and Aim: Nowadays, considering the occurrence of various diseases as a result of inflammation, finding a solution for inflammations caused by various factors is very important. Therefore, the aim of the present study was to investigate the effect of eight weeks of endurance training and complementation on the levels of CD22 and TRL4 in obese wistar rats.
Materials and Methods: In an experimental study, 40 Wistar rats of two-month age range, were purchased from Pasteur Institute of Karaj and divided into four groups (each group including 10 animals) of high-fat diet without intervention, endurance training group, only olive supplement, and the olive supplement group with endurance training. Animals in the training groups underwent a two-month endurance training program (80% maximal oxygen consumption). Also, in the olive oil supplement group, one gram of olive oil per kg body weight was fed daily through oral gavage. ELISA method was used to evaluate serum TLR4 and CD22 levels, Shapiro-Wilk test was used to evaluate the normal distribution of samples, and one-way and two-way ANOVA were run for the purpose of between groups comparisons (p<0.05).
Results: The results showed that two months of endurance training alone do not have a significant effect on inflammation )TLR4 (P=0.09), CD22(P=0.16)) in obese male Wistar rats. However, consumption of olive oil alone significantly reduced TLR4 (P = 0.009) and CD22 (P = 0.008). This is while two months of endurance training with oil consumption had no significant effect on TLR4 (P = 0.09) and CD22 (P = 0.10).
Conclusion: It seems that consumption of olive oil can reduce obesity-induced inflammation (TLR4) to some extent. However, further research is needed to fully reveal this.