Research in Medicine

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khansooz M, palizvan M, saremi A. Changes in heart risk markers after an increased endurance training period in infected rats. Research in Medicine 2021; 45 (4) :60-65
URL: http://pejouhesh.sbmu.ac.ir/article-1-2943-en.html

Background: In patients with myocardial infarction, preventing the deposition of lipoproteins in the vascular wall is an important factor in rapid recovery and functional capacity returns doing exercise. Therefore, the aim of the present study was to investigate the effect of increasing endurance training on the risk of cardiovascular risk factors in infant specimens.
Materials and Methods: A total of 20 Wistar rats aged 8-10 weeks with a mean weight of 230±30g were divided into two groups of infarction control (MI.Co) and infarction (MI.Ex). After inducing experimental myocardial infarction with two intraperitoneal isoproterenol injections at a dose of 150 mg/kg for 24 hours, the exercise group performed an endurance training protocol on the treadmill for eight weeks. Applying the same conditions followed at least 24 hours after the last training session. To examine the significant changes in the levels of Cholesterol, TG, LDL, and HDL, independent t-tests were run in Graph Pad program.
Findings: Serum LDL and TG levels in the infarct training group decreased significantly (2.12 and 13.87 mg/dl, respectively) compared with the infarct control group (p=0.03). However, cholesterol and HDL levels increased in the infarct training group, as compared with the infarct control group (5.25 and 4.12 mg/dl, respectively), which was observed to be significant only in HDL levels (p=0.03).
Conclusion: It seems that the use of non-pharmacological strategies, such as increased endurance training, can significantly reduce LDL and TG levels and, in turn, significantly increase HDL levels in patients with myocardial infarction.