, m.galedari@iauahvaz.ac.ir
Abstract: (71 Views)
Background and Aim: VEGF is an important angiogenic factor which expression and plasma levels are affected by obesity and its effects can be health-promoting or disease-inducing. The aim of this study was to evaluate the effect of six weeks of interval training on vascular smooth muscle VEGF gene expression in male rats on a high-fat diet
Materials and Methods: In an experimental study, 40 male rats were randomly divided into four groups: 1) control (standard diet), 2) high fat diet 1 (eight weeks high fat diet), 3) high fat diet 2 (14 weeks high fat diet), 4) High-fat diet and intermittent exercise). Animals in groups 2 to 5 first ate a high-fat diet (60% of calories from fat) for eight weeks. In the eighth week of the high-fat diet group 1, in order to determine the level of VEGF at the beginning of the training intervention, facilitation and sampling were performed. Periodic training consisted of 5 to 12 60-second runs of 24 to 32 meters per minute and light work intervals of 75 seconds for six weeks (to ensure oxidative compatibility with interval training) and five days a week. Real Time PCR technique was measured. Mann-Whitney test was used to compare the groups.
Results: The results of the present study showed that eight weeks of high-fat diet significantly increased the expression of VEGF gene in vascular smooth muscle of male rats compared to the control group (P = 0.001 .(VEGF gene expression was significantly lower than eight weeks after 14 weeks of high-fat diet (P = 0.005(. VEGF gene expression after six weeks of interval training was significantly lower than eight weeks of high-fat diet (P = 0.001 .(and was not significantly different from the 14-week high-fat and control groups.
Conclusion: Interval training can possibly reduce angiogenesis by reducing VEGF expression in visceral adipose tissue vessels and thus prevent adipose tissue development.
Materials and Methods: In an experimental study, 40 male rats were randomly divided into four groups: 1) control (standard diet), 2) high fat diet 1 (eight weeks high fat diet), 3) high fat diet 2 (14 weeks high fat diet), 4) High-fat diet and intermittent exercise). Animals in groups 2 to 5 first ate a high-fat diet (60% of calories from fat) for eight weeks. In the eighth week of the high-fat diet group 1, in order to determine the level of VEGF at the beginning of the training intervention, facilitation and sampling were performed. Periodic training consisted of 5 to 12 60-second runs of 24 to 32 meters per minute and light work intervals of 75 seconds for six weeks (to ensure oxidative compatibility with interval training) and five days a week. Real Time PCR technique was measured. Mann-Whitney test was used to compare the groups.
Results: The results of the present study showed that eight weeks of high-fat diet significantly increased the expression of VEGF gene in vascular smooth muscle of male rats compared to the control group (P = 0.001 .(VEGF gene expression was significantly lower than eight weeks after 14 weeks of high-fat diet (P = 0.005(. VEGF gene expression after six weeks of interval training was significantly lower than eight weeks of high-fat diet (P = 0.001 .(and was not significantly different from the 14-week high-fat and control groups.
Conclusion: Interval training can possibly reduce angiogenesis by reducing VEGF expression in visceral adipose tissue vessels and thus prevent adipose tissue development.
Type of Study: Original |
Subject:
Physical Education and Sports Science ( Sport physiology- Sport biomecanic
Received: 2021/07/19 | Accepted: 2022/04/24
Received: 2021/07/19 | Accepted: 2022/04/24
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This Journal is licensed under a Creative Commons Attribution 4.0 International License | Research in Medicine
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