Volume 48, Issue 3 (12-2024)
Research in Medicine 2024, 48(3): 52-61 |
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Ethics code: IR.SSU.MEDICINE.REC.1400.137
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Javadzadeh Shahshahani H, Akhavan Tafti F, Vaziri M. Evaluation of Laboratory Tests for Detecting SARS-CoV-2 Antibodies in COVID-19 Convalescent Plasma Donors in Yazd City, 2020-2021. Research in Medicine 2024; 48 (3) :52-61
URL: http://pejouhesh.sbmu.ac.ir/article-1-3253-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3253-en.html
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. , javadzadehhayedeh@gmail.com
Abstract: (253 Views)
Background and Aim: Plasma therapy in patients with COVID-19 is one of the first treatment methods in the world and in Iran as well. It is necessary to determine whether the donated plasma has detectable antibodies for therapeutic use. Therefore, the present study was performed to determine the frequency of rapid tests, ELISA, and antibody titers of SARS- CoV-2 in the plasma of recovered COVID-19 patients.
Methods: The study was observational and cross-sectional. Donors who recovered from COVID-19 and donated blood or plasma from May 2020 to the end of May 2021 were included in the study by census method. Samples were taken for rapid tests, ELISA tests, and titration. Laboratory test results and data, including age, history of hospitalization, and interval from infection to plasma donation, were entered into SPSS20, and analysis was performed with descriptive and analytical (Chi- Square) statistical tests.
Results: 1826 donors aged 18-64 participated in this study. 59.6% of donors had an antibody titer of 160 and above. In 89% of donors who had a positive antibody titer, the rapid test was also positive, and in 98.4% of them, the ELISA test was positive (p < 0.001). A correlation was observed between donor age and antibody titer (p < 0.001). There was no significant relationship between the antibody titer and the time interval between the disease and plasma donation. The antibody titer in the donors who were hospitalized was significantly higher than the donors who were treated at home (p < 0.001).
Conclusion: There was a significant correlation between positive rapid test and ELISA with high antibody titer. Donors, who had a positive rapid test and ELISA, were admitted to the hospital, and donors who were older had a high antibody titer in their donated plasma.
Methods: The study was observational and cross-sectional. Donors who recovered from COVID-19 and donated blood or plasma from May 2020 to the end of May 2021 were included in the study by census method. Samples were taken for rapid tests, ELISA tests, and titration. Laboratory test results and data, including age, history of hospitalization, and interval from infection to plasma donation, were entered into SPSS20, and analysis was performed with descriptive and analytical (Chi- Square) statistical tests.
Results: 1826 donors aged 18-64 participated in this study. 59.6% of donors had an antibody titer of 160 and above. In 89% of donors who had a positive antibody titer, the rapid test was also positive, and in 98.4% of them, the ELISA test was positive (p < 0.001). A correlation was observed between donor age and antibody titer (p < 0.001). There was no significant relationship between the antibody titer and the time interval between the disease and plasma donation. The antibody titer in the donors who were hospitalized was significantly higher than the donors who were treated at home (p < 0.001).
Conclusion: There was a significant correlation between positive rapid test and ELISA with high antibody titer. Donors, who had a positive rapid test and ELISA, were admitted to the hospital, and donors who were older had a high antibody titer in their donated plasma.
Type of Study: Original |
Subject:
Hematology
Received: 2023/02/18 | Accepted: 2024/11/10 | Published: 2025/01/20
Received: 2023/02/18 | Accepted: 2024/11/10 | Published: 2025/01/20
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