Volume 48, Issue 2 (8-2024)
Research in Medicine 2024, 48(2): 1-11 |
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Ethics code: IR.IAU.DENTAL.REC.1399.225
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Sohrabi M, Alirezaei S, Anvari Digehsara M, Alaee A. Comparison of Curcumin and Mefenamic Acid in Controlling Pain and Swelling after Open Sinus Lift Surgery for Implant Reconstruction (A Clinical Trial Study). Research in Medicine 2024; 48 (2) :1-11
URL: http://pejouhesh.sbmu.ac.ir/article-1-3343-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3343-en.html
Oral and Maxillofacial Department, Faculty of Dentistry, Islamic Azad University of Medical Sciences, Tehran, Iran. , arezoo.alaee@yahoo.com
Abstract: (622 Views)
Background and Aim: Sinus lift and subsequent bone grafting is a very accepted method of implant placement for edentulous rehabilitation in the posterior of the maxilla. Complications after sinus lift surgery include pain and swelling in the surgical area. Based on theexistence of multiple effects of curcumin around inflammation and pain, no wide research about this issue, and increasing the usage of herbal medicine among patients, this study aimed to compare curcumin and mefenamic acid in controlling pain and swelling after open sinus lift surgery for implant reconstruction.
Methods: This randomized clinical trial study was performed on 90 patients who volunteered for open sinus lift surgery in the posterior maxilla. They were randomly divided into two groups (n = 45). Pain after surgery was assessed based on the VAS scale. Inflammation was assessed by a ruler at 24, 48 and 72 hours after surgery. Data were analyzed using SPSS software version 22, independent t-test and Mann- Whitney U. The p-value less than 0.05 (p < 0.05) was considered significant.
Results: 51 men and 39 women participated in our study (p < 0.05). The mean age in the mefenamic acid group was 34.7 ± 7.9 and in the curcumin group, was 37.7 ± 9.2 (p > 0.05). The mean pain and swelling in both groups at all times after surgery were determined by VAS and a ruler. Pain and swelling were significantly lower in curcumin compared to the mefenamic acid group (p < 0.0001). There was a significant difference between the pain levels of the patients in the two-by-two time comparison (p < 0.05(. The effect of the drug on patients' pain over time was significant (p < 0.05). The effect of drug, time, and the interaction between drug and time on patients' swelling over time was significant (p < 0.0001).
Conclusion: It seems that curcumin may be a good alternativefor mefenamic acid after oral surgery.
Methods: This randomized clinical trial study was performed on 90 patients who volunteered for open sinus lift surgery in the posterior maxilla. They were randomly divided into two groups (n = 45). Pain after surgery was assessed based on the VAS scale. Inflammation was assessed by a ruler at 24, 48 and 72 hours after surgery. Data were analyzed using SPSS software version 22, independent t-test and Mann- Whitney U. The p-value less than 0.05 (p < 0.05) was considered significant.
Results: 51 men and 39 women participated in our study (p < 0.05). The mean age in the mefenamic acid group was 34.7 ± 7.9 and in the curcumin group, was 37.7 ± 9.2 (p > 0.05). The mean pain and swelling in both groups at all times after surgery were determined by VAS and a ruler. Pain and swelling were significantly lower in curcumin compared to the mefenamic acid group (p < 0.0001). There was a significant difference between the pain levels of the patients in the two-by-two time comparison (p < 0.05(. The effect of the drug on patients' pain over time was significant (p < 0.05). The effect of drug, time, and the interaction between drug and time on patients' swelling over time was significant (p < 0.0001).
Conclusion: It seems that curcumin may be a good alternativefor mefenamic acid after oral surgery.
Type of Study: Original |
Subject:
dentistry
Received: 2023/11/11 | Accepted: 2024/03/12 | Published: 2024/09/16
Received: 2023/11/11 | Accepted: 2024/03/12 | Published: 2024/09/16
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