Volume 31, Issue 2 (9-2007)                   Research in Medicine 2007, 31(2): 177-186 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fatemi F, Dadkhah A, Honardoost M, Ebrahimi S, Hedayati M. Biochemical mechanism of inflammation in colorectal cancer. Research in Medicine. 2007; 31 (2) :177-186
URL: http://pejouhesh.sbmu.ac.ir/article-1-399-en.html
, Hedayati@erc.ac.ir
Abstract:   (14727 Views)
Biological and chemical stimulators cause tissue injury. Many epidemiological studies imply that chronic stimulation of tissues leads to cancer. One of the most important type of chronic tissue stimulation criteria is increased activity of the metabolic pathway of arachidonic acid and production of biochemical intermediates. Cyclooxygenase pathway (COX) of arachidonic acid leads to production of a variety of prostaglandins and thromboxanes. These inflammatory agents exert their biological effects on different organs and initiate human cancers. Lately, a variety of synthetic and natural drugs have been discovered that suppress the production of these inflammatory agents and inhibit cancer promotion. One of the most popular drugs, are non-steroidal anti-inflammatory drugs, (NSAIDs). In this review, we discuss the role of these inflammatory agents in colorectal carcinogenesis and also their mechanism of inhibition.
Full-Text [PDF 371 kb]   (3781 Downloads)    
Type of Study: Review |
Received: 2008/02/24 | Published: 2007/09/15

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This Journal is licensed under a Creative Commons Attribution 4.0 International License  | Research in Medicine

Designed & Developed by : Yektaweb