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- , safarzadeh.gargari@yahoo.com
Abstract:   (323 Views)
Purpose: Exercise training and antioxidant consumption is one of the important factors in preventing the sarcopenia and apoptosis in aging muscles. The aim of this study was the effects of aerobic exercise and vitamin D supplementation on apoptosis and sarcopenia in aging rats.
Material and methods: In this experimental study 50 aging rats (20-2 month) (220±20 weight g ) randomly divided in to five groups of ten rats consist of: control(C), Salin (S), vitamin D(VD), training(T) and vitamin D + training (VDT). Exercise groups have been ran on treadmill four days a week in eight weeks with specific speed and10% incline and also vitamin D injected to rat .05µg on daily. BAX , BCL-2, follistatin and myostatin proteins were assessed 24 hr after last exercise and in anesthetic state on soleus muscle. all data analyzed by one way ANOVA and scheffe at level of P<0.05.
Result: BAX and myostatin significantly decreased in VDT and T groups compared to control group (p=0.013 for myostatin and P=0.03 for BAX in VDT group, P=0.017 for myostatin and P=0.027 for BAX in T group)also follistatin and BCL-2 were significant increased in this groups (P=0.01 for follistatin and P=0.01 for BCL-2 in VDT group, P=0.005 for follistatin and P=0.024 for BCL-2 in T group)  BAX/BCL-2 ratio significant decreased in between groups but no significant difference was observed in myostatin and follistatin ratio between groups (P>0.05).
conclusion: it seems that eight concurrent aerobic training can attenuated apoptosis such as BAX and BCL-2 and sarcopenia consist of myostatin and follistatin variable in rat muscles and if this training with vitamin D consumption it may prevented the muscle apoptosis and sarcopenia in aging rats. 
Keyword: cell death, sarcopenia, aerobic training, vitamin D
     
Type of Study: Original | Subject: Physical Education and Sports Science ( Sport physiology- Sport biomecanic
Received: 2019/04/19 | Accepted: 2019/07/30

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