Research in Medicine

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yousefi L, Tehranipour M, Zafar balanezhad S. Effect of hydroalcoholic extract of wheat (Triticum sativum) on sex hormones in Wistar rats. Research in Medicine 2020; 44 (4) :540-548
URL: http://pejouhesh.sbmu.ac.ir/article-1-2082-en.html

Background and Objective: The importance of fertility and its issues, as the most important factor in changing population size, has led to an increase in fertility studies and related issues. Infertility is an active impotence. Wheat is the scientific name Triticum Sativum Lam belongs to the family Poaceae. Wheat germ is one of the largest germ of flowering plants. Considering the high consumption of wheat by Iranians and the fact that infertility is one of the problems that affects the family, the aim of this study was to evaluate the effect of administration of Triticum sativum hydroalcoholic extract on estrogen, progesterone, luteinizing (LH) and follicle stimulating hormones (FSH) in adult female rats.
Materials and Methods: This experimental study was performed on 30 female rats in the range of 200-250 mg and approximately 3 months in 5 groups of 6, including control, positive control and 50, 100 and 150 mg / kg doses of wheat hydro-alcoholic extract. Prescriptions were taken as gavage for 21 days. At the end of treatment, after taking blood samples, the levels of estrogen, progesterone, LH and FSH were measured and Data were analyzed using Minitab6 software and ANOVA and t-test.
Results: . Results showed that wheat had a significant increase in the levels of progesterone (p = 0.03), estrogen (p = 0.04), LH (p = 0.03) and FSH (p = 0.0) compared to the control group.
Conclusion: It seems that the use of wheat hydroalcoholic extract increased the levels of progesterone, estrogen, LH and FSH.Probably high levels of LH secretion increase the level of FSH, activation of the apple and subsequent production of progesterone from granulosa cells in the corpus luteum.