Research in Medicine

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Abstract Background: Presence of the beta-lactamase enzyme results in microbial resistance to beta-lactam and cell wall synthesis inhibitor antibiotics. This study was conducted to compare effects of Calendula officinalis extract and cephalosporines, as a cell wall synthesis inhibitor antibiotic, on bacteria isolated from patients with cellulitis. Methods: This experimental study was done on bacteria isolated from 100 patients. Calendula officinalis extract was prepared by perculation with methanol 85%. Solvent was vaporized and lyophilized. Antibacterial effects of the herb extract, cefixim, cephalexin, ceftriaxone, ceftizoxime, and cefazolin were evaluated by two methods of disc diffusion and MIC. Statistical analysis was performed by ANOVA and paired t- test. Results: Streptococcus pyogenes, Enterococcus fecalis, Staphylococcus, (MRSA) and Staphylococcus saprophiticus were susceptible in dilutions of 1:128 of Calendula officinalis extract. In disc diffusion, 100% of Streptococcus, Enterococcus fecalis, MRSA and 50% of Staphylococcus saprophiticus were susceptible to Calendula officinalis extract. Gram negative bacteria, including E.coli, Proteus, Klebsiella, Serattia, and Pseudomonas were resistant. Diameter of no growth of bacteria among gram positive and negative bacteria was significantly different in Calendula officinalis extract (p< 0.001). Conclusion: It seems that Calendula officinalis extract can be used in combination with antibiotics for the treatment of cellulitis. KEYWORDS: Calendula officinalis, Cephalosporines, Drug Resistance, Cellulitis, Gram positive bacteria.

Keywords: KEYWORDS: Calendula officinalis, Cephalosporines, Drug Resistance, Cellulitis, Gram positive bacteria.

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