Research in Medicine

Background: Hyperlipidemia is one of risk factor in cardiovascular diseases, with regard to possible effect of Elaegnus angustifolia this study aimed at evaluating the effect of E. angustifolia leaf extract on lipid profiles in normal and fed with hyperlipidemic diet rats which was conducted in 2014 in the laboratory of the Faculty of Science, Islamic Azad University of Hamedan.
Materials and methods: 30 male rats (150 g) were divided in five groups control, treated with lovastatin (10 mg/kg, p.o, for one week) and treated with E. angustifolia extract (300 mg/kg, p.o, for one week) randomly. All groups (except control group) fed with hyperlipidemic diet (20% sheep oil) for 5 weeks. At the end of experiment and after 12 h fasting, the blood samples were collected from heart directly and plasma lipid concentrations were measured using the ELISA method. Data were analyzed by analysis of variance test using SPSS software and difference between data with p<0.05 considered significant.
Results: The data showed that the feeding animals with hypelipidemic diet was increased weight animals and was caused hyperlipidemia in serum (p<0.01). E. angustifolia leaf extract significantly decrease plasma triglyceride (57.5±4.7) and LDL (37.5±2.9) and increase HDL (18.8±1.2) in obese rat (p<0.01), but it did not show significant effect on decreasing serum cholesterol level.
Conclusion: It seems that consumption of E. angustifolia leaf extract could have significant favorable effects on the lipid and weight profiles of obese rats.