Volume 11, Issue 3 And 4 (March 1987)                   Research in Medicine 1987, 11(3 And 4): 122-131 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rezaei Poor R. Generation and Evaluation of Monoclonal Autoantibodies in Systemic Lupus Erythematosis. Research in Medicine 1987; 11 (3 and 4) :122-131
URL: http://pejouhesh.sbmu.ac.ir/article-1-2538-en.html
Generation and Evaluation of Monoclonal Autoantibodies in Systemic Lupus Erythematosis
Robabeh Rezaei Poor
Department of Microbiology and Immunology, Faculty of Mecicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (1855 Views)
Three murine monoclonal anti-ssDNA autoantibodies have been produced by fusion of spleen cells from NZB/NZW F1 hybrid mice with Sp2/0-Ag 14 murine myeloma cells. Specificity studies characterizing monoclonal anti - ssDNA autoantibodies revealed binding patterns for nucleotides. Clone E-4-1 showed preferential binding with mono-di-and polyguanosine. Clones E-4-4 and E-11-1 specitically bound mono-di-and polythymidine. Results of inhibition studies indicated an order of reactivity for each monoclonal autoantiby; polynucleotide) dinucleotide) mononucleotide. 
Keywords: Autoantibodies, Lupus, Monoclonal
Full-Text [PDF 4853 kb]   (785 Downloads)    
Type of Study: Review | Subject: Interdisciplinary (Educational Management, Educational research, Statistics, Medical education
Received: 1986/11/27 | Accepted: 1987/06/10 | Published: 1987/12/4
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Creative Commons License
This Journal is licensed under a Creative Commons Attribution 4.0 International License  | Research in Medicine

Designed & Developed by : Yektaweb