Research in Medicine

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Ghiasvand N M. Antibiotics. Research in Medicine 1985; 8 (3 and 4) :208-219
URL: http://pejouhesh.sbmu.ac.ir/article-1-2714-en.html

The use of antibiotics has immensely helped the medical profession in controling and treatli'ent of infectious disease since J.940 However, there has been problems and disappointments along the wayi.e.wide-spread rise of resistant bacteria from previously sensitive ones & antibiotic antagonism.Many factors have helped to precipitate these problems,which the preventable, missuse of antibiotics being an important one. 
To use antibiotics properly and effectively, doctors need to know the modes of action of these widely used drugs. Antibac­terial drugs, while almost harmlessto eucaryotic cells, kill sensitive bacteria with different mechanisms. Some antibiotics kill the sensitive microbes by competing with cellular metabo­lits, some inhibit biosynthesis of DNA, RNA and proteins, and some interfere with the structure and function of crl.lular or­gans, such as cell wall and cytoplasmic.