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Background and Aim: Immobility and limitation of movement are the cause of many diseases, including cardiovascular disease. Cardiovascular diseases are the leading diseases associated with inactivity and the leading cause of death in the world. One of the main factors in the prevention and treatment of these diseases is exercise. Since choosing the right exercise program for these patients is very important and limited research has been done in this field; Therefore, the aim of this study was to investigate the effect of a period of combined and interval training on the amount of C-reactive protein and galactin in heart patients.
 
Methods: In this Clinical trial study, 36 cardiovascular patients(With mean age of 55/14 ± 1/4, weight of 78/6 ± 5/1 and body mass index of 27/81 ±0/33) were selected voluntarily And after simulation, samples divided into 3 groups: combined training group (n = 13), interval training group (n = 12) and control group (n = 11). ). Inclusion criteria included no functional capacity less than 5 meters, no tachycardia and bradycardia, and injection fraction greater than 30. Exclusion criteria also included a physician's diagnosis and unwillingness to continue activity. The protocol of the combined training group consisted of performing 2-3 times a week of Continuous aerobic training without performing interval training during the first 4 weeks, then performing 2 times a week of Continuous aerobic training and performing once a week of interval training during the second 4 weeks. The protocol of the interval training group included performing 2-3 times a week of interval training during the first 4 weeks and performing 3 times a week of interval training during the second 4 weeks. Blood samples were taken 24 hours before the first training session and 48 hours after the last training session (under the same conditions for all three groups). Data analysis was performed using paired sample t-test , ANCOVA and post hoc(Scheffe test) at a significance level of P˂0/05.
Results: Performing combined training and interval training had a significant effect on reducing the serum levels of C-reactive protein in combined training by 1/59 ± 0/11, P˂0/05, in periodic training by 1/03 ± 0/08, P˂0/001 Showed. Also, the rate of change of galactin-3 in combined training was 4/51 ± 0/28, P˂0/05, in periodic training was 2/32 ± 0/14, P˂0/004 in comparison with the control group with values of 0/034 ± 0/002, P˂0/316 was observed. Combined exercise also reduced these two indices further than periodic exercise in reactive protein C by 0/56 ±  0/011 and in galactin-3 by 2/.19 ± 0/31. In comparison between the groups with the analysis of covariance, the intergroup changes for reactive protein C were 1/38 ± 0/15, P˂0/001 and for galactin-3 was 1/05 ± 0/11, P˂0/001.
Conclusion: Combined training and interval training are likely to reduce the serum levels of C-reactive protein and galactin-3 in cardiovascular patients, further reducing the levels of these two inflammatory markers( high levels of which are a sign of cardiovascular disease). As a result, combination training is likely to be more effective than interval training  in reducing heart disease risk factors. And can be prescribed to improve the health of heart patients.
     
Type of Study: Applicable | Subject: Interdisciplinary (medicine and humanities)
Received: 2021/06/21 | Accepted: 2021/12/25

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