Volume 48, Issue 3 (12-2024)
Research in Medicine 2024, 48(3): 1-8 |
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Ethics code: IR.IAU.TNB.REC.1401.029
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Honarpour A, Majd A, Mirfakhraie R, Jamaldini S H, Rahimi M, Salimi Nasab S. Investigating the Role of ACVR2A Gene Expression in Preeclamptic Placentas.. Research in Medicine 2024; 48 (3) :1-8
URL: http://pejouhesh.sbmu.ac.ir/article-1-3399-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3399-en.html
Asal Honarpour 
, Ahmad Majd , Reza Mirfakhraie , Seyed Hamid Jamaldini , Maryam Rahimi , Sina Salimi Nasab
, Ahmad Majd , Reza Mirfakhraie , Seyed Hamid Jamaldini , Maryam Rahimi , Sina Salimi Nasab
Department of Biology, North Tehran Branch, Iran Islamic Azad University, Tehran, Iran. , Ahmad_majd2005@yahoo.com
Abstract: (338 Views)
Background and Aim: Preeclampsia is a significant condition during pregnancy, and if left untreated, it increases the risk of maternal and fetal mortality. Abnormal placentation is widely recognized as the primary cause of this disorder. Increased expression of Activin A, which plays a crucial role in placental and fetal development, has been confirmed in patients with preeclampsia. However, the mechanism of action of the Activin A receptor (ACVR2A) remains unclear. Therefore, this study examined the expression of the ACVR2A gene in the placentas of women with preeclampsia compared to those of healthy pregnant women.
Methods: In this case- control study, the expression of the ACVR2A gene in 40 placental samples, including 20 from women with preeclampsia and 20 from healthy pregnant women, was analyzed using quantitative Real- Time PCR (qPCR). The expression changes between the two groups were assessed with REST software, and the expression variation charts were plotted using T-test and Mann- Whitney statistical tests in GraphPad Prism software.
Results: increased expression of the ACVR2A gene was observed in the placentas of women with preeclampsia compared to normal placentas . The placenta in the preeclampsia group showed a 5.5-fold increase in gene expression compared to the control group.
Conclusion: It appears that the upregulation of ACVR2A gene expression plays a role in the development of preeclampsia.
Methods: In this case- control study, the expression of the ACVR2A gene in 40 placental samples, including 20 from women with preeclampsia and 20 from healthy pregnant women, was analyzed using quantitative Real- Time PCR (qPCR). The expression changes between the two groups were assessed with REST software, and the expression variation charts were plotted using T-test and Mann- Whitney statistical tests in GraphPad Prism software.
Results: increased expression of the ACVR2A gene was observed in the placentas of women with preeclampsia compared to normal placentas . The placenta in the preeclampsia group showed a 5.5-fold increase in gene expression compared to the control group.
Conclusion: It appears that the upregulation of ACVR2A gene expression plays a role in the development of preeclampsia.
Type of Study: Original |
Subject:
Genetic
Received: 2024/08/10 | Accepted: 2024/10/28 | Published: 2025/01/20
Received: 2024/08/10 | Accepted: 2024/10/28 | Published: 2025/01/20
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