Volume 48, Issue 4 (2-2025)
Research in Medicine 2025, 48(4): 0-0 |
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Aliaghaei A, Sadrinasab S. The effects of tramadol on neurological diseases (a review article). Research in Medicine 2025; 48 (4)
URL: http://pejouhesh.sbmu.ac.ir/article-1-3439-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3439-en.html
Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , abbas.aliaghaei@sbmu.ac.ir
Abstract: (106 Views)
Background and Aim: Neurological diseases such as Alzheimer's and Parkinson's are among the most important diseases that, in addition to cognitive and motor effects, are often associated with chronic pain. Tramadol is used as an analgesic drug in the management of pain in these patients, but its effects on the central nervous system and cognitive and motor functions are still debated.
Methods:The type of study is review article. Data collection is taken from reliable scientific databases such as Pubmed. This article examines the mechanisms of Tramadol's effect and its effects on Alzheimer's and Parkinson's patients. Considering the analgesic effects of tramadol through the inhibition of serotonin and norepinephrine reabsorption as well as the activity on opioid receptors, its side effects such as cognitive disorders, drowsiness and movement problems in these patients should be carefully considered.
Conclusion:Studies show that tramadol can aggravate cognitive function in Alzheimer's patients and increase movement problems in Parkinson's patients. It seems that tramadol can be useful as a treatment option to reduce pain in patients with neurological diseases such as Alzheimer's and Parkinson's, but the issues related to drug side effects should also be considered.
Methods:The type of study is review article. Data collection is taken from reliable scientific databases such as Pubmed. This article examines the mechanisms of Tramadol's effect and its effects on Alzheimer's and Parkinson's patients. Considering the analgesic effects of tramadol through the inhibition of serotonin and norepinephrine reabsorption as well as the activity on opioid receptors, its side effects such as cognitive disorders, drowsiness and movement problems in these patients should be carefully considered.
Conclusion:Studies show that tramadol can aggravate cognitive function in Alzheimer's patients and increase movement problems in Parkinson's patients. It seems that tramadol can be useful as a treatment option to reduce pain in patients with neurological diseases such as Alzheimer's and Parkinson's, but the issues related to drug side effects should also be considered.
Keywords: Tramadol, Alzheimer's, Parkinson's, Neuroinflammation, Oxidative stress, Central nervous system.
Type of Study: Review |
Subject:
Pharmacy: (Pharmacology, Pharmaceutical Economy)
Received: 2024/12/22 | Accepted: 2025/03/1 | Published: 2025/03/11
Received: 2024/12/22 | Accepted: 2025/03/1 | Published: 2025/03/11
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