Volume 31, Issue 4 (7-2007)
Research in Medicine 2007, 31(4): 339-343 |
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Eslami G, Golshani M, Rakhshan M, Fallah F, Goudarzi H, Taghavi A. Surveying human papiloma virus (HPV) in patients with bladder cancer by PCR. Research in Medicine 2007; 31 (4) :339-343
URL: http://pejouhesh.sbmu.ac.ir/article-1-447-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-447-en.html
, g_eslami@yahoo.com
Abstract: (17809 Views)
Background: Bladder cancer is the second prevalent cancer of urogenital tract, affecting males 3 more commonly than females. Different risk factors have been proposed, among which viral infections, especially HPV, have been explained recently. The present study surveyed HPV and its associated types in patients with bladder cancer using PCR technique.
Materials and methods: A total of 186 patients, including 147 cases and 39 controls were biopsied and HPV frequency and its associated types were determined by PCR
Results: Totally, 34.7% of cases and 7.6% of controls were HPV positive. HPV18 was the most frequent type (47%). Males were 6 times more frequently affected than females. Most of the cases were aged 51-60 years.
Conclusion: With respect to the high frequency rate of HPV among patients with bladder cancer when compared with controls, HPV seems to be significantly associated with bladder cancer.
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