Showing 9 results for Yousefi
F Homaie, Z Yousefi, N Sharifi, M Khajedalouie, V Mousavi Torshizi,
Volume 32, Issue 1 (6-2008)
Abstract
Background: Cervical carcinoma is the second most common cancer among women worldwide. In the Middle East it is the most common malignancy in women. Prognostic utility of squamous cell carcinoma antigen (SCCAg) for cervical cancer, and its correlation with pathologic grading has been demonstrated in several studies. However, no such study has been performed in Iran. The aim of the present study was to investigate the frequency of SCCAg and its correlation with histological stage and grade of tumor in blood samples from cervical cancer patients.
Materials and methods: Patients referred to the oncology center of Qhaem hospital in Mashad, during a three-year period, from 1382-1385, were included in the study. Previously untreated patients, and subjects in whom no other parts of body were involved with squamous cell carcinomas, were selected. Pretreatment serum SCCAg levels were measured by RIA.
Results: 52 patients qualified for the study. The average age of patients was 52.9 years. The most common presenting sign was bleeding (94.1%). 35 patients (64.8%) were in stage II 26 patients (48%) had grade 1 tumor. 29 patients (55.7%) had positive levels for SCCAg with the average of 15.37 ng/ml and median of 10 ng/ml. According to primary evaluations, there was a significant difference in the level of serum SCCAg with size, stage, grade of tumor and lymph node metastases.
Conclusion: SCCAg was positive in a high percentage of patients with cervical squamos cell carcinoma. It may be regarded as a tumor marker in this cancer.
Hedayatollah Shirzad, Mahbubeh Yousefi, Sorayya Ghasemi, Maryam Shirzad, Seyfollah Borjian Broujeni, Mahmud Rafiian,
Volume 34, Issue 3 (11-2010)
Abstract
Abstract
Background: Stress gradually suppresses the immune system making the body susceptible to various diseases. The aim of this study was to show the effects of cold and immobilization stress on growth of malignant cells in Balb/c mice.
Methods: In an experimental study which was carried out in the Molecular & Cellular Research Center of Shahrekord University of Medical Sciences in 2008, 3 groups of 10 Balb/c mice were selected to investigate the effects of cold stress and immobilization stress on growth of WEHI – 164 fibrosarcoma cells in groups of 10, Balb/c mice. Each mouse was injected with tumor cells subcutaneously in the chest for 2 hours/day mice in group 1were subjected to cold stress and mice in group 2 were immobilized the control group received tumor cells with no stresses. Tumor sizes were measured every two days and case groups were compared with the control group.
Results: Results showed that the tumor sizes in stressed mice were significantly different from controls. After 14 days of tumor inoculation, mean tumor size in mice subjected to cold stress and immobilization was 31.99±2.61 and 37.13±3.51cumm respectively, but in the control group the mean tumor size was 18.15±3.09 cumm, (p<0.05) .
Conclusion: Results in this study showed that cold and immobilization stresses increase the growth of WEHI-164 tumor cells.
Keywords: Stress, Cancer, Immune system, Cold stress, Immobilization stress.
Mohammad Reza Yousefi, Nasoor Ahmad, Mohammad Reza Abbaszadeh, Sina Rokhsati,
Volume 35, Issue 4 (2-2012)
Abstract
Abstract
Background: The aim of this study was to examine the effect of isometric training on prevention of bone density reduction of limbs during an immobilization period.
Methods: In this quasi-experimental study, 60 men with fractures of the femoral bone, needing at least one month immobilization period, were selected and randomly assigned in control and experimental groups, the latter undergoing isometric training . The amount of bone density was measured by DEXA set. The data were inferentially analyzed using independent t-test.
Results: Isometric training in immobilization period after injury prevented loss of mineral density in neck and greater trochanter of femoral bone, and also significantly increased the mineral density of femoral bone in the experimental group.
Conclusion: Isometric exercises not only prevent reduction of bone density, but may also increase the mineral density of the injured bone.
KEYWORDS: Injury, Lower limb, Immobilization period, Femur bone.
Babak Babakhani, Mohammad Reza Abbasian, Narges Hosseini Tabatabaei, Mehrdad ,mokarram, Javad Yousefi, Ahmad ,dizangian, Nasim Siatiri,
Volume 37, Issue 4 (2-2014)
Abstract
Abstract Background: Osteoarthritis is the most common joint disease in a large number of old people that can cause pain and disability. Intra-articular injection is one of the recommended procedures to reduce this pain. In this issue some disagreements about analgesic effect of marcaine's (a trade name for bupivacaine) intra-articular injection for post operation pain due to knee surgeries has been seen. Materials and Methods: In this double-blind randomized clinical trial study, 22 patients with osteoarthritis were involved. Those have been electively referred to orthopedic and pain clinic of Zahedan'skhatam-alanbia hospital between 2010 and 2011. One of the patient's knees randomly considered as case knee and another knee as control. Before any intervention each knee's pain was measured from 1 to 10 by Numeric Rating Scale (NRS) and has been recorded. Then 4ml of 0.5% marcaine injected in case knee and 4ml saline injected in control. After 5 minutes, without removing the needle from the joint, synovial fluid aspirated, and aspiration pain measured with the same NRS scale. Afterward 40mg methylprednisolone was injected in both knees. Then pain separately measured in 1, 6, and 24 hours and finally one week after aspiration. Data were recorded and processed by SPSS software, version 18. Moreover, the paired test and Anova test were used for data analysis. Results: In this study 22 patient, 12 female (54.5%) and 10 men (45.5%) were attended. The age average was 55.09 years and they were between 38 and 72 years old. Comparisons showed significant differences between case and control group in pain (P<0.001). Conclusion: Intra-articular injections of marcaine can significantly relieves the pain after knee joint aspiration in patients with osteoarthritis, and it can be useful in this category. Keywords: Osteoarthritis, Pain, Knee aspiration, Marcaine.
Davar Amani, Roya Yousefi,
Volume 41, Issue 4 (12-2017)
Abstract
Abstract
Background: In the serum of healthy people, IgG4 has lowest concentration among the different sub-classes of IgG. Elevation of serum IgG4 in response to chronic antigenic stimulation and inflammation has been reported. Inflammation, histopathologic lesions and systemic organ involvement have been reported in the IgG4-related disease (IgG4-RD). In this article we review IgG4 unique features and its role in immunopathogenesis of IgG4RD; new class of human disease. Also we discuss the IgG4 roles and its therapeutic potential in tumor.
Method: We systematically searched the Pub Med, Google Scholar, Scopus and Science Direct databases with IgG4, IgG4 related disease and IgG4-RD key words .Finally, Seventy four English language articles reporting IgG4 and IgG4 RD were included.
Conclusion and Recommendations: IgG4-RD is classified as rare diseases and to date exact prevalence of it has not been reported. In recent years the disease features have been described, but a long way is ahead of scientists to understand of IgG4RD mechanisms. The role of humoral (antibody) immune response against tumor antigens is the main interest of scientists. Histological studies in some tumors such as melanoma show the presence of anti-tumor antibodies within inflammatory tumor lesions. Unique biological property of IgG4, such as the ability to switch Fab arms, results in inhibition of immune complex formation and ineffective antibody dependent cell killing.IgG4 as blocking antibody has protective role in allergy by inhibiting the release of mast cells granules. Also in malignant melanoma, IgG4 suppresses antitumor immune response via inhibition of IgG1 binding to tumor cells. These finding emphasis that, new investigations are necessary for understanding the importance of IgG4 in health and diseases.
Mahdieh Azizi, Roya Yousefi, Farshid Yeganeh, Mostafa Haji Molla Hoseini,
Volume 43, Issue 2 (7-2019)
Abstract
Background: There are reports on the ability of chitin microparticles to modulate the TH1 and TH2
responses, depending on the size and administration route. The purpose of the present study was to
investigate the immunoadjuvant effects of the small-sized (less than 40 microns) chitin microparticles
(CMP) in vaccination against Leishmania major for preventing leishmaniasis in BALB /c mice by
determining IgG1 and IgG2a.
Methods: BALB⁄c mice in test and control groups (6 mice per group), during 21 days were immunized
subcutaneously three times with soluble Leishmania antigens (SLA) or SLA/CMP. Three weeks after the
last immunization, blood sampling was performed and immunoglobulin isotype was determined using
ELISA. Then 2 × 105 L. major promastigotes were injected into the base of the tail of the mice. Next, onset
and size of the lesions were measured in each group. In the eighth week, blood samples were obtained from
the eye for evaluation of IgG1 and IgG2a level and then the mice were sacrificed and their lymph nodes
were isolated to determine the parasitic burden using Limiting dilution assay (LDA).
Results: The SLA / CMP-immunized mice in compared to the non-immunization group, the onset of the
wound were postponed and the parasitic load [(0.41±3.9 Vs.0.82±5.8 Log (Parasites per lymph node)]
(P≤0.05) and the extended area of the wound (P≤0.007) were significantly decreased. The results of
the serum IgG1 and IgG2a assay showed that immunization by chitin microparticles caused significant
decrease in the serum IgG1 level before (P≤0.001) and after (P≤0.014) the challenge but not IgG2a.
Conclusion: Co-administration of CMP/SLA cause significant inhibition of IgG1 responses. It seems that
CMP could downregulate unbridled TH2 response in Leishmania infection.
Mr Seyed Mohammad Hosseini, Hossein Yousefi-Banaem, Hooman Bahrami Motlagh, Mehdi Salehi Barough,
Volume 44, Issue 3 (9-2020)
Abstract
Background and purpose: Most exposure of people to artificial sources through diagnostic radiographs is due to the increase of these tests in the community and the inevitability of these tests. Optimizing the dose of skin inlet can play an important role in reducing radiation exposure, which can be achieved by monitoring the inlet dose as a key parameter.
The purpose of this study was to evaluate the rate of skin input dose in routine radiographic tests at Loghman Hakim Hospital in Tehran to compare the doses recommended by the International Commission for Protection against Radiation (ICRP) as well as, if possible, to provide simple guidelines for dose reduction and optimization. Patients with preserved image quality.
Materials and Methods: This descriptive study was performed in Loghman Hakim public hospital in Tehran with 235 patients 100 females and 135 males with a weight range of ± 10 kg. In this study, skin doses of patients were measured using four diagnostic radiographs of IAEA standards, in 12 common radiographic views using thermoluminescence chips and Geiger Müller dosimeter.
Results: The doses of skin for each radiographic method in milligrays were as follows: Chest (posterior-anterior) 0.34, Chest (1.85), Abdominal (anterior-posterior) 3.31 , Hip (anterior-posterior) 4.79, cervical (anterior-posterior) 1.95, cervical vertebra (1.24), dorsal (anterior-posterior) 2.38, dorsal vertebrae (profile) 4.68), lumbar vertebrae 3.95, lumbar vertebrae 9.53, skull (antero-posterior) 29.2 and skull 1.89.
Conclusion: This study shows that the rate of skin inlet dose in the twelve investigated facets was in accordance with the recommended doses and was in line with the standards provided by the International Commission for Protection against ICRP and also optimized the radiation parameters. And standardizing radiographic conditions by preserving the image quality will reduce the dose received by patients. In this regard, dosimetry at regular intervals and periodic and regular quality control tests of radiographic devices can be optimized, monitored, reduced dose. And protecting patients as well as assessing potential harm The object of radiation will be effective.
Leila Yousefi, Maryam Tehranipour, Saeedeh Zafar Balanezhad,
Volume 44, Issue 4 (12-2020)
Abstract
Background and Objective: The importance of fertility and its issues, as the most important factor in changing population size, has led to an increase in fertility studies and related issues. Infertility is an active impotence. Wheat is the scientific name Triticum Sativum Lam belongs to the family Poaceae. Wheat germ is one of the largest germ of flowering plants. Considering the high consumption of wheat by Iranians and the fact that infertility is one of the problems that affects the family, the aim of this study was to evaluate the effect of administration of Triticum sativum hydroalcoholic extract on estrogen, progesterone, luteinizing (LH) and follicle stimulating hormones (FSH) in adult female rats.
Materials and Methods: This experimental study was performed on 30 female rats in the range of 200-250 mg and approximately 3 months in 5 groups of 6, including control, positive control and 50, 100 and 150 mg / kg doses of wheat hydro-alcoholic extract. Prescriptions were taken as gavage for 21 days. At the end of treatment, after taking blood samples, the levels of estrogen, progesterone, LH and FSH were measured and Data were analyzed using Minitab6 software and ANOVA and t-test.
Results: . Results showed that wheat had a significant increase in the levels of progesterone (p = 0.03), estrogen (p = 0.04), LH (p = 0.03) and FSH (p = 0.0) compared to the control group.
Conclusion: It seems that the use of wheat hydroalcoholic extract increased the levels of progesterone, estrogen, LH and FSH.Probably high levels of LH secretion increase the level of FSH, activation of the apple and subsequent production of progesterone from granulosa cells in the corpus luteum.
Dr Amir Shahram Yousefi Kashi,
Volume 45, Issue 3 (9-2021)
Abstract
Background: Breast cancer (BC) is the most common visceral cancer among Iranian women with 13400 new cases annually. A few studies have reported that BC patients with p53 expression had different prognosis and clinical outcome. The aim of the present study was to evaluate and compare clinical outcome and prognostic factors in Iranian breast cancer patients with p53 expression.
Methods and materials: In a longitudinal study, 801 BC patients who had referred to and were followed by Cancer Research Center, from 2003 to 2017, were divided into two groups: 300 patients with p53 expression (positive) and 501 patients without p53 expression (negative). Then, clinical outcome and prognostic factors for these two gr oups were evaluated and compared.
Results: The patients with positive and negative p53 represented %37.5 and %62.5 of the cases with the mean ages of 44.2 years (SD=9.4) and 47.7 years (SD=10.9), respectively (p<0.0001). There were more advanced stage and lymph node involvement, more positive lymphovascular invasion and Premenopausal status, higher degrees of negative estrogen receptor (ER) status, and positive human epidermal receptor 2 (HER2) expression in patients with positive p53 in comparison to those with negative p53 (p=0.0162, p=0.0047, p=0.0296, p=0.0339, p=0.0374, and p=0.0494, respectively). In patients with positive and negative p53, five years disease free survival were %81 and 86.4 %, (p=0.0413) and five years overall survival wer e %70 and 76.8 %, respectively (p=0.0323).
Conclusions: Our study showed better clinical outcomes and favorable prognostic factors in patients without p53 expression compared with those with p53 expression.
