Volume 48, Issue 2 (8-2024)
Research in Medicine 2024, 48(2): 60-80 |
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Sheikholeslami M A, Parvardeh S, Ghafghazi S. Therapeutic Application of Curcumin in Various Diseases. Research in Medicine 2024; 48 (2) :60-80
URL: http://pejouhesh.sbmu.ac.ir/article-1-3373-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3373-en.html
Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , masheikh@sbmu.ac.ir
Abstract: (221 Views)
Background and Aim: Curcumin is the active ingredient of the turmeric plant (Curcuma longa) from the ginger family (Zingiberaceae). The medicinal properties of this plant have been known and used for thousands of years. Today we know that turmeric is a rich source of two main products: polyphenols (curcuminoids) and essential oils. Curcumin is the main natural polyphenol in turmeric rhizomes. Research has shown that curcumin has strong anti-inflammatory and antioxidant properties. These effects of curcumin have caused this compound to be used as an effective supplement in the treatment of various diseases such as; Pain, diabetes, addiction, central nervous system diseases, skin diseases, cardiovascular diseases, etc.
Methods: The present study reviewed related investigations up to 2024 by searching keywords such as turmeric, curcumin, curcumin with skin diseases, cardiovascular diseases, digestive diseases, central nervous system diseases, addiction, lung diseases, skin diseases, cancerous tumors, cancer, diabetes, and aging; Cheched in PubMed databases. Among the collected articles, the articles that were most related to the goals of writing this article were selected and studied.
Conclusion: Research shows that curcumin is a potent antioxidant and anti-inflammatory and a tolerable compound in humans. The permissible daily intake of curcumin based on JECFA (Joint FAO/ WHO Expert Committee on Food Additives) and EFSA (European Food Safety Authority) is up to 3 mg/ kg. Of course, in various studies, daily consumption of up to 12 grams of safe and non-toxic curcumin has been mentioned. Considering that curcumin is a very effective compound in the treatment of many diseases and is used as a supplement in some diseases in our country; And on the other hand, the therapeutic effect of this combination has been proven in various diseases; In this review article, we examined the effect of curcumin in the treatment and improvement of various diseases. It should be noted that so far, no article has been presented that examines the effect of curcumin on various diseases.
Methods: The present study reviewed related investigations up to 2024 by searching keywords such as turmeric, curcumin, curcumin with skin diseases, cardiovascular diseases, digestive diseases, central nervous system diseases, addiction, lung diseases, skin diseases, cancerous tumors, cancer, diabetes, and aging; Cheched in PubMed databases. Among the collected articles, the articles that were most related to the goals of writing this article were selected and studied.
Conclusion: Research shows that curcumin is a potent antioxidant and anti-inflammatory and a tolerable compound in humans. The permissible daily intake of curcumin based on JECFA (Joint FAO/ WHO Expert Committee on Food Additives) and EFSA (European Food Safety Authority) is up to 3 mg/ kg. Of course, in various studies, daily consumption of up to 12 grams of safe and non-toxic curcumin has been mentioned. Considering that curcumin is a very effective compound in the treatment of many diseases and is used as a supplement in some diseases in our country; And on the other hand, the therapeutic effect of this combination has been proven in various diseases; In this review article, we examined the effect of curcumin in the treatment and improvement of various diseases. It should be noted that so far, no article has been presented that examines the effect of curcumin on various diseases.
Keywords: Turmeric, Curcmin, Diseases, Central nervous system (CNS), Skin, Cardiovascular, Neurology
Type of Study: Review |
Subject:
Pharmacy: (Pharmacology, Pharmaceutical Economy)
Received: 2024/03/12 | Accepted: 2024/05/12 | Published: 2024/09/16
Received: 2024/03/12 | Accepted: 2024/05/12 | Published: 2024/09/16
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