Volume 49, Issue 3 (12-2025)
Research in Medicine 2025, 49(3): 0-0 |
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Ethics code: IR.IAU.TON.REC.1398.007
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Zahmatkesh R, Tajdar M. Association of -1486T/C TLR9 gene polymorphism with risk of peptic ulcer and Helicobacter pylori infection. Research in Medicine 2025; 49 (3)
URL: http://pejouhesh.sbmu.ac.ir/article-1-3426-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3426-en.html
Department of Cell and Molecular biology, Ton.C , Islamic Azad University, Tonekabon, Iran. , zahmatkesh.rasoul@gmail.com
Abstract: (3 Views)
Background and Aim: Peptic ulcers (PUD) cause open sores in the lining of the stomach or duodenum, and Helicobacter pylori infection is a major cause. TLRs play an important role in detecting Helicobacter pylori infection, regulating and activating the host immune system against it. TLR-9 activates the immune system signaling pathway by recognizing the DNA of bacteria invading host epithelial cells. The aim of this study was to investigate the association between TLR9 gene -1486T/C polymorphism and the risk of PUD and Helicobacter pylori infection.
Methods: In this case-control study, 96 patients with PUD and Helicobacter pylori infection and 104 healthy individuals were investigated. The genotypic frequency of the -1486T/C polymorphism of the TLR9 gene was determined by PCR-RFLP method and the data were analyzed by chi-square test.
Results: The results of statistical analysis showed that there was a significant difference in the frequency of CC genotype (P=0.001, CI=1.62-8.76, OR=3.77) and C allele frequency (P=0.0002, CI=1.41-3.23, OR=2.13) between patients with PUD and H. pylori infection and controls.
Conclusion: The presence of the C allele at the -1486T/C polymorphism of the TLR9 gene appears to be associated with the risk of peptic ulcer and Helicobacter pylori infection in the studied population. However, further studies on larger and more diverse populations are needed to confirm or refute this finding.
Methods: In this case-control study, 96 patients with PUD and Helicobacter pylori infection and 104 healthy individuals were investigated. The genotypic frequency of the -1486T/C polymorphism of the TLR9 gene was determined by PCR-RFLP method and the data were analyzed by chi-square test.
Results: The results of statistical analysis showed that there was a significant difference in the frequency of CC genotype (P=0.001, CI=1.62-8.76, OR=3.77) and C allele frequency (P=0.0002, CI=1.41-3.23, OR=2.13) between patients with PUD and H. pylori infection and controls.
Conclusion: The presence of the C allele at the -1486T/C polymorphism of the TLR9 gene appears to be associated with the risk of peptic ulcer and Helicobacter pylori infection in the studied population. However, further studies on larger and more diverse populations are needed to confirm or refute this finding.
Type of Study: Original |
Subject:
Genetic
Received: 2024/10/28 | Accepted: 2025/10/18 | Published: 2026/02/16
Received: 2024/10/28 | Accepted: 2025/10/18 | Published: 2026/02/16
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