Research in Medicine

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Background: The present study was designed to assess the effect of Mg, Zn, vitamin C and E supplements on microalbuminuria and urinary albumin excretion and N-acetyl-β-D-glucosaminidase activity (βNAG) in type 2 diabetic patients. Materials and methods: In a randomized, double-blind, placebo controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups and received one of the following daily supplement for 3 months group M: 200 mg Mg and 30 mg Zn (n=16), group V: 200 mg vitamin C and 100 IU vitamin E (n=18), group MV: minerals plus vitamins (n=17), group P: placebo (n=18). Serum malondialdehyde concentration as well as urine microalbumin concentration and βNAG activity and blood pressure were measured at the baseline and following the intervention. Results: Results have revealed that following the intervention urinary albumin decreased in V and MV groups. Urinary βNAG activity and protein concentration did not change significantly however, malondialdehyde concentration was significantly decreased in M and MV groups. Finally, systolic, diastolic and mean blood pressure decreased significantly in the MV group. Conclusion: Our findings indicate that a combination of vitamin and mineral could decrease urinary concentration of microalbumin in type 2 diabetic patients. Thus, these supplements could be prescribed to improve renal function in type 2 diabetic patients

Keywords: : Vitamin C, Vitamin E, Magnesium, Zinc, Micoalbuminuria, βNAG.

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