Volume 49, Issue 2 (9-2025)
Research in Medicine 2025, 49(2): 0-0 |
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Ethics code: IR.SBMU.AEC.1402.026
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Sheikholeslami M A, Zamani M R, Parvardeh S, Farjoo M H. The effect of glucosamine and tranexamic acid on acute wound healing caused by incision in mice.. Research in Medicine 2025; 49 (2)
URL: http://pejouhesh.sbmu.ac.ir/article-1-3479-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3479-en.html
, masheikh@sbmu.ac.ir
Abstract: (10 Views)
Background and Aim: Wound healing is a complex, multi-phase process influenced by local, systemic, and pharmacological factors. Glucosamine and tranexamic acid, owing to their anti-inflammatory and tissue-reparative properties, are compounds that may positively influence tissue regeneration. This study aimed to evaluate the effects of topical glucosamine and tranexamic acid, individually and in combination, on the healing rate of acute surgical wounds in mice.
Materials and Methods: In this experimental laboratory study, 25 male mice were randomly assigned to 5 groups: untreated control, 20% glucosamine, 6% tranexamic acid, and a combination of both. After generating full-thickness excisional wounds on the dorsal neck region using a biopsy punch, the topical formulations were applied daily for 12 consecutive days. Wound healing progression was assessed on days 1, 3, 5, 7, and 10 using digital imaging, and wound area was quantified using ImageJ software. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test.
Results: Comparative analysis of wound sizes across time points revealed no statistically significant differences between any of the treatment groups (glucosamine, tranexamic acid, or their combination) and the control group (P > 0.05).
Conclusion: Despite previous reports suggesting beneficial effects of glucosamine and tranexamic acid on wound repair, the present study demonstrated that topical application of these agents at the tested doses did not significantly accelerate the healing rate of acute surgical wounds in mice.
Materials and Methods: In this experimental laboratory study, 25 male mice were randomly assigned to 5 groups: untreated control, 20% glucosamine, 6% tranexamic acid, and a combination of both. After generating full-thickness excisional wounds on the dorsal neck region using a biopsy punch, the topical formulations were applied daily for 12 consecutive days. Wound healing progression was assessed on days 1, 3, 5, 7, and 10 using digital imaging, and wound area was quantified using ImageJ software. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test.
Results: Comparative analysis of wound sizes across time points revealed no statistically significant differences between any of the treatment groups (glucosamine, tranexamic acid, or their combination) and the control group (P > 0.05).
Conclusion: Despite previous reports suggesting beneficial effects of glucosamine and tranexamic acid on wound repair, the present study demonstrated that topical application of these agents at the tested doses did not significantly accelerate the healing rate of acute surgical wounds in mice.
Type of Study: Original |
Subject:
dermatology
Received: 2025/07/14 | Accepted: 2025/09/6 | Published: 2025/12/13
Received: 2025/07/14 | Accepted: 2025/09/6 | Published: 2025/12/13
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