Volume 31, Issue 3 (10-2007)                   Research in Medicine 2007, 31(3): 241-245 | Back to browse issues page

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Amirmozafari N, Tehrani HF, Tavaf Langeroodi Z, Abdullahi A. Survey of drug resistance due to extended spectrum β-lactamases in Klebsiella pneumoniae strains isolated from hospitalized patients . Research in Medicine 2007; 31 (3) :241-245
URL: http://pejouhesh.sbmu.ac.ir/article-1-414-en.html
Survey of drug resistance due to extended spectrum β-lactamases in Klebsiella pneumoniae strains isolated from hospitalized patients
Amirmozafari N , Tehrani HF , Tavaf Langeroodi Z , Abdullahi A
Abstract:   (16703 Views)
Background: Klebsiella pneumoniae is one of the most important and prevalent bacterium isolated from clinical cases especially from hospitalized patients. Recent studies have focused on multiple drug resistant K.pneumoniae strains. In this survey, drug resistance in clinical isolates was studied with special reference to extended spectrum β-lactamase. Methods: A total of 303 K.pneumoniae strains isolated from hospitalized patients were initially surveyed for drug resistance by disc diffusion method. The resistance of the isolated strains to different antibiotics was determined by E-test. β-lactamase production was tested with nitrocephin discs and extended spectrum β-lactamase assays were performed with double disc synergy tests. Results: From the total of 303 K.pneumoniae isolates tested, 62, (20.4%), showed multi drug resistance, (MDR). All of these MDR strains were positive for nitrocephin test, indicating β-lactamase production. Double disc synergy tests results showed production of extended spectrum β-lactamase in all MDR isolates. Conclusion: Detection of 20.4% MDR strains, especially extended spectrum β-lactamase, from K. pneumoniae isolated from hospitalized patients, emphasizes the potential dangers of the widespread usage of extended spectrum cephalosporins. It also necessitates conduction of a wider study to determine the nationwide incidence of K. pneumoniae.
Keywords: Klebsiella pneumoniae, Extended spectrum β-lactamase (ESBL), Multiple Drug Resistance (MDR).
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Type of Study: Original | Subject: Microbiology
Received: 2008/04/19 | Published: 2007/10/15
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