Volume 50, Issue 1 (5-2026)
Research in Medicine 2026, 50(1): 0-0 |
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Zamani P, Ahadi P, Eghtedari F, Asdagh Z, Bahrami M. The Effect of Vitamin D In Female Fertility and Pregnancy Outcomes, A Review. Research in Medicine 2026; 50 (1)
URL: http://pejouhesh.sbmu.ac.ir/article-1-3514-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3514-en.html
, dr.ahadi8290@gmail.com
Abstract: (45 Views)
Introduction: Infertility, a profound and growing challenge, currently affects approximately one-sixth of couples worldwide. Beyond its well‑known role in bone health, vitamin D has increasingly been recognized as a potential contributor to women’s reproductive health and pregnancy outcomes. Deficiency of this vitamin is common among women of reproductive age and during pregnancy, and may be associated with adverse maternal and neonatal outcomes. Despite the substantial increase in research on the role of vitamin D in female fertility, significant scientific gaps remain, underscoring the need for a comprehensive narrative review in this field.
Methods: This study was conducted as a narrative review. A literature search was performed in PubMed, Scopus, Web of Science, and Google Scholar, and a selection of English-and Persian-language articles published in recent years that examined the role of vitamin D in female fertility and pregnancy were reviewed.
Results and Discussion: The evidence suggests that vitamin D deficiency is associated with an increased risk of infertility, ovulatory dysfunction, gestational diabetes, preeclampsia, preterm birth, and intrauterine growth restriction. Several studies also indicate that vitamin D supplementation may improve certain maternal and neonatal outcomes, including birth weight and maternal metabolic status, although findings from interventional studies remain inconsistent.
Conclusion: Vitamin D plays a significant role in fertility and pregnancy health. Monitoring vitamin D levels and correcting deficiencies in pregnant women-particularly those at high risk-may offer clinical benefits; however, further high‑quality studies are needed to determine the optimal dosage and establish definitive efficacy.
Methods: This study was conducted as a narrative review. A literature search was performed in PubMed, Scopus, Web of Science, and Google Scholar, and a selection of English-and Persian-language articles published in recent years that examined the role of vitamin D in female fertility and pregnancy were reviewed.
Results and Discussion: The evidence suggests that vitamin D deficiency is associated with an increased risk of infertility, ovulatory dysfunction, gestational diabetes, preeclampsia, preterm birth, and intrauterine growth restriction. Several studies also indicate that vitamin D supplementation may improve certain maternal and neonatal outcomes, including birth weight and maternal metabolic status, although findings from interventional studies remain inconsistent.
Conclusion: Vitamin D plays a significant role in fertility and pregnancy health. Monitoring vitamin D levels and correcting deficiencies in pregnant women-particularly those at high risk-may offer clinical benefits; however, further high‑quality studies are needed to determine the optimal dosage and establish definitive efficacy.
Type of Study: Review |
Subject:
Midwifery
Received: 2026/01/14 | Accepted: 2026/05/31 | Published: 2026/10/17
Received: 2026/01/14 | Accepted: 2026/05/31 | Published: 2026/10/17
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