Volume 50, Issue 1 (5-2026)
Research in Medicine 2026, 50(1): 85-95 |
Back to browse issues page
Ethics code: 0
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Zamani P, Ahadi P, Eghtedari F, Asdagh Z, Bahrami M. The Effect of Vitamin D in Female Fertility and Pregnancy Outcomes, a Review. , Research in Medicine. 2026; 50 (1) :85-95
URL: http://pejouhesh.sbmu.ac.ir/article-1-3514-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3514-en.html
Department of Pediatrics, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. , dr.ahadi8290@gmail.com
Abstract: (403 Views)
Background and Aim: Infertility, a profound and growing challenge, currently affects approximately one- sixth of couples worldwide. Beyond its well- known role in bone health, vitamin D has increasingly been recognized as a potential contributor to female reproductive health and pregnancy outcomes. Vitamin D deficiency is common among women of reproductive age and during pregnancy and may be associated with adverse maternal and neonatal outcomes. Despite the substantial increase in research on the role of vitamin D in female fertility, significant scientific gaps remain, underscoring the need for a comprehensive narrative review of this field.
Methods: This study was conducted as a narrative review. A literature search was performed in PubMed, Scopus, Web of Science, and Google Scholar, and selected English- and Persian- language articles published in recent years that examined the role of vitamin D in female fertility and pregnancy were reviewed.
Results: The evidence suggests that vitamin D deficiency is associated with an increased risk of infertility, ovulatory dysfunction, gestational diabetes, preeclampsia, preterm birth, and intrauterine growth restriction. Several studies also indicate that vitamin D supplementation may improve certain maternal and neonatal outcomes, including birth weight and maternal metabolic status, although findings from interventional studies remain inconsistent. Vitamin D may play an important role in fertility and pregnancy health. Monitoring vitamin D levels and correcting deficiencies in pregnant women, particularly those at high risk, may offer clinical benefits; however, further high-quality studies are needed to determine the optimal dosage and establish definitive efficacy.
Methods: This study was conducted as a narrative review. A literature search was performed in PubMed, Scopus, Web of Science, and Google Scholar, and selected English- and Persian- language articles published in recent years that examined the role of vitamin D in female fertility and pregnancy were reviewed.
Results: The evidence suggests that vitamin D deficiency is associated with an increased risk of infertility, ovulatory dysfunction, gestational diabetes, preeclampsia, preterm birth, and intrauterine growth restriction. Several studies also indicate that vitamin D supplementation may improve certain maternal and neonatal outcomes, including birth weight and maternal metabolic status, although findings from interventional studies remain inconsistent. Vitamin D may play an important role in fertility and pregnancy health. Monitoring vitamin D levels and correcting deficiencies in pregnant women, particularly those at high risk, may offer clinical benefits; however, further high-quality studies are needed to determine the optimal dosage and establish definitive efficacy.
Type of Study: Review |
Subject:
Midwifery
Received: 2026/01/14 | Accepted: 2026/05/31 | Published: 2026/10/17
Received: 2026/01/14 | Accepted: 2026/05/31 | Published: 2026/10/17
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This Journal is licensed under a Creative Commons Attribution 4.0 International License | Research in Medicine
Designed & Developed by : Yektaweb