Volume 50, Issue 1 (5-2026)
Research in Medicine 2026, 50(1): 0-0 |
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Ethics code: IR.SBMU.RIES.REC.1394.117
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Asgari S, Hadaegh P, Rahmani F. Blood Pressure Changes and 20-Year Incident Cardiovascular Disease: Tehran Lipid and Glucose Study. Research in Medicine 2026; 50 (1)
URL: http://pejouhesh.sbmu.ac.ir/article-1-3549-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3549-en.html
Prevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. & Clinical Research and Development Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , dr.rahmani.fatemeh@gmail.com
Abstract: (19 Views)
Background and Aim: To assess the relationship between changes in blood pressure (BP), measured between 1999-2001 and 2002-2005, and the 20-year incidence of cardiovascular disease (CVD).
Methods: In 3569 Iranian individuals aged ≥30 years, systolic blood pressure, diastolic BP, mean arterial pressure (MAP), and pulse pressure (PP) were evaluated at two consecutive visits. Participants were then followed for cardiovascular events. Multivariable-adjusted Cox proportional hazards models were used to assess the associations between changes in BP components and CVD risk, adjusting for age, sex, baseline BP, traditional cardiovascular risk factors, and their changes.
Results: During a median follow-up of 20 years after the second examination, 589 CVD events occurred. A 1-SD increase in systolic BP, diastolic BP, and MAP was significantly associated with 13%, 18%, and 17% increased risks of CVD, respectively, after adjustment for baseline BP components and other common risk factors (all p-values <0.05). Importantly, the association with diastolic BP change remained significant after further adjustment for systolic BP change. Change in PP showed no significant association with CVD.
Conclusion: Changes in systolic BP, diastolic BP, and MAP were significantly associated with subsequent CVD incidence in a middle- aged Iranian population. Consequently, tracking BP trends over time may serve as a valuable indicator of future CVD risk.
Methods: In 3569 Iranian individuals aged ≥30 years, systolic blood pressure, diastolic BP, mean arterial pressure (MAP), and pulse pressure (PP) were evaluated at two consecutive visits. Participants were then followed for cardiovascular events. Multivariable-adjusted Cox proportional hazards models were used to assess the associations between changes in BP components and CVD risk, adjusting for age, sex, baseline BP, traditional cardiovascular risk factors, and their changes.
Results: During a median follow-up of 20 years after the second examination, 589 CVD events occurred. A 1-SD increase in systolic BP, diastolic BP, and MAP was significantly associated with 13%, 18%, and 17% increased risks of CVD, respectively, after adjustment for baseline BP components and other common risk factors (all p-values <0.05). Importantly, the association with diastolic BP change remained significant after further adjustment for systolic BP change. Change in PP showed no significant association with CVD.
Conclusion: Changes in systolic BP, diastolic BP, and MAP were significantly associated with subsequent CVD incidence in a middle- aged Iranian population. Consequently, tracking BP trends over time may serve as a valuable indicator of future CVD risk.
Type of Study: Original |
Subject:
Cardiology
Received: 2026/07/3 | Accepted: 2026/08/3 | Published: 2026/10/17
Received: 2026/07/3 | Accepted: 2026/08/3 | Published: 2026/10/17
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