Volume 36, Issue 5 (2-2013)                   Research in Medicine 2013, 36(5): 104-110 | Back to browse issues page

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Bakhtiar S, Babakhani A, Maleki M H, Zaherara M, Davoodian E, Sayeh Miri K et al . The relationship between rs2970847 polymorphism of PGC-1α gene and susceptibility to type 2 diabetes: a systematic review and meta-analysis . Research in Medicine 2013; 36 (5) :104-110
URL: http://pejouhesh.sbmu.ac.ir/article-1-1117-en.html
Department of Statistics and Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Abstract:   (8936 Views)
Abstract Background: PGC-1α is involved in the regulation of several metabolic processes and its reduced expression has been observed in early stages of type 2 diabetes, (T2D). Changes in activity of PGC-1α, probably due to its polymorphisms, have extensive effects on metabolic processes in people with T2D. The association of rs2970847 polymorphism of PGC-1α gene with T2D has been investigated in several studies, but the results of these studies are diverse and sometimes contradictory. The aim of this meta-analysis was to investigate the relationship between Thr394Thr polymorphism of PGC-1α gene and T2D. Materials and Methods: This study was a systematic review of the available literature and resources. To find related documents, the following literature databases were searched: Scopus, PubMed, Google scholar, SID, Irandoc and Magiran. Articles were searched by combining critical and sensitive keywords, including: rs2970847, Thr394Thr polymorphism, PPARGC1A, PGC-1, PGC1alpha, Type 2 diabetes, type 2 diabetes, and T2D. Results: In 7 reviewed papers, the total number of T2D and control subjects was 2146 and 2814, respectively. For the GG, GA, and AA genotypes of the Thr394Thr polymorphism, OR (95% CI) were equal to 0.59 (95% CI=0.52-0.67), 1.25 (1.10-1.43), and 1.75 (1.45-2.08), respectively. The results showed that the association between the GG and GA genotypes of Thr394Thr polymorphism and susceptibility to T2D was statistically significant (P <0.05). Conclusion: This study generally demonstrated that rs2970847 polymorphism of PGC-1α gene is significantly associated with the risk of T2D. Keywords: PGC-1α, T2D, Thr394Thr polymorphism, rs2970847, Meta-analysis.
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Type of Study: Original | Subject: Interdisciplinary (Educational Management, Educational research, Statistics, Medical education
Received: 2013/04/17 | Accepted: 2013/05/4 | Published: 2013/05/4

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