Volume 42, Issue 2 (6-2018)                   Research in Medicine 2018, 42(2): 106-109 | Back to browse issues page

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Mirmosayyeb O, Mmanouchehri N, Toghiani N T, Dehghani A, Golabchi K, Dehghani L, et al . Evaluation of retinal nerve fiber layer thickness in relapsing remitting multiple sclerosis: a prospective study. Research in Medicine. 2018; 42 (2) :106-109
URL: http://pejouhesh.sbmu.ac.ir/article-1-1823-en.html
Isfahan University of Medical Sciences, Isfahan, , Shaygannejad@med.mui.ac.ir
Abstract:   (3237 Views)
Background: Previous studies suggest that retinal nerve fiber layer (RNFL) thickness decreases over time in multiple sclerosis (MS) and can be a marker of disease activity for patients’ follow-up. Here, we aimed to compare RNFL thickness in patients with relapsing remitting MS (RRMS) during three years of follow-up.
Methods: During this prospective study, patients with diagnosis of RRMS and history of optic neuritis were included in the study. Demographic features and disease characteristics were collected and they underwent Optical coherence tomography (OCT). OCT was repeated after three years and obtained amounts were compared.
Results: A total of 12 patients (11 women) with mean age of 35.6 ± 6.1 years and mean disease duration of 5.3 ± 5.8 were included in the study. RNFL thickness was 101.27 ± 9.15μm and 92.00 ±7.96 μm in the left eye at the baseline and after 3 years, respectively (P-value<0.001). In the right eye, RNFL thickness was 99.72 ± 16.37 μm and 86.36 ± 20.35 μm at the baseline and after 3 years, respectively (p=0.014). 
Conclusions: We found a significant decrease in RNFL thickness in RRMS patients after 3 years of follow up, in spite of getting immunomodulatory treatment. We recommend OCT as an inexpensive and feasible tool for outcome measurement in RRMS patients.
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Type of Study: Original | Subject: Norology
Received: 2017/11/14 | Accepted: 2018/02/24 | Published: 2018/07/14

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