Volume 44, Issue 4 (12-2020)                   Research in Medicine 2020, 44(4): 573-579 | Back to browse issues page

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Delfan M, Peeri M, Ghouchi Asl S. The comparison of eight weeks of high intensity interval training vs. continuous training on the genes expression of IL-6 and CRP in adipose tissue of diabetic Rats induced by high-fat foods and fructose. Research in Medicine. 2020; 44 (4) :573-579
URL: http://pejouhesh.sbmu.ac.ir/article-1-2075-en.html
Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra university, Tehran, Iran , m.delfan@alzahra.ac.ir
Abstract:   (2129 Views)
Background: Adipose tissue plays an important role in type 2 diabetes pathogenesis by secreting different adipokines, such as IL6- and CRP. Regarding the role of physical activity in reducing inflammatory factors and uncertainty about the most effective models of training, the aim of the present study was to compare the effects of eight weeks of continuous and high-intensity interval training (HIIT) on the IL6- and CRP gene expression in adipose tissue of type 2 diabetic Rats. 
Methods: After induction of type 2 diabetes (with seven months of high-fat diet containing %30 fat and %25 fructose), a total of 21 male Wistar rats were divided into three groups of control, continuous training, and HIIT. Continuous and HIIT training programs were performed for eight weeks and five sessions per week.IL6- and CRP expressions were determined using Real Time PCR assay. Data were analyzed running oneway analysis of variance and Tukey post-hock test at the significance level set at p≤05 .0.
Results: A significant decrease in IL6- gene expression was observed in HIIT and continuity groups compared to the control group (p <0.001) and the decrease in IL6- expression in HIIT group was significant as compared to the continuity group (p = 0.022). This rate in the continuity and periodicity groups were 0.09±0.38 and 06.±0.62, respectively; a significant decrease in CRP expression was observed in both trained groups compared to the control group (0.001>p). This rate in the continuity and periodicity groups were 0.6 0.6 /1 and 0.56 ± 0.056, respectively.
Conclusion: HIIT seems to be more effective in reducing adipose tissue inflammation compared with continuous training.
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Type of Study: Original | Subject: Physical Education and Sports Science ( Sport physiology- Sport biomecanic
Received: 2019/07/14 | Accepted: 2019/11/27 | Published: 2020/06/27

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