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Tabriz university of medical sciences , Rezazadeh.mary@gmail.com
Abstract:   (385 Views)
Background and Aim: Autism Spectrum Disorder (ASD) is a developmental disease of the nervous system that affects an average of 1 in 150 children worldwide. Both genetic and environmental factors play a role in the development of this range of disorders. Several studies have shown an association between vitamin D receptor (VDR) gene polymorphisms and behavioral disorders of the nervous system. In the present study, our aim was to investigate the association of VDR gene polymorphisms rs731236 (Taq1), rs1544410 (BsmI), rs2228570 (FokI) with the risk of autism.
Materials and Methods: In this case-control study, 50 patients with ASD and 50 healthy control children were studied following the polymerase chain reaction on DNA extracted from peripheral blood and then enzymatic digestion with RFLP technique in terms of genotypic and allelic distribution studies.
Results: The results of statistical analysis of genotypic and allelic distribution for FokI and BMSI types of VDR gene did not show a significant difference between patients with autism and control group (p≤0.05).  But Allelic and genotypic distribution of TT and tt genotypes between case and control groups showed a significant difference.
Conclusion: These results provide early evidences that genetic alterations in the VDR (TaqI) gene may alter children's susceptibility to ASD.
     
Type of Study: Original | Subject: Genetic
Received: 2021/07/1 | Accepted: 2021/11/27

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