Volume 46, Issue 4 (12-2022)
Research in Medicine 2022, 46(4): 124-131 |
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Alaei M, Alaei F, Habibi N, Farahbakhsh N. Congenital Heart Disease Accompanying Congenital Hypothyroidism and Related Factors, a Study in Mofid Children’s Hospital. Research in Medicine 2022; 46 (4) :124-131
URL: http://pejouhesh.sbmu.ac.ir/article-1-3176-en.html
URL: http://pejouhesh.sbmu.ac.ir/article-1-3176-en.html
Department of Pediatric Cardiology, Mofid Children’s Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , alaeifariba@yahoo.com
Abstract: (786 Views)
Background and Aim: Congenital hypothyroidism results from abnormal structure, position, or hormone production of the thyroid gland. Since common genetic and developmental pathways exist, congenital heart disease may accompany it.
Methods: In this cross- sectional descriptive study, 75 children with congenital hypothyroidism were evaluated by echocardiography using the census method. They had been detected during the national screening program of neonates; the diagnosis had been documented then. Patients with Down syndrome, low birth weight, and less than 1-month age were excluded from the study. Mean and standard deviations for quantitative variants and frequency for qualitative variants were applied. Student’s test- test, Pearson’s chi- square, and correlation index were used for data analysis.
Results: Congenital heart disease was detected in 20% of these hypothyroid children, including 12% atrial septal defect, 4% atrial and ventricular septal defects, and 4% mitral valve prolapse. Patent foramen ovale was detected in 21 children. No cardiac abnormality was reported in 52% of children. Gestational age and birth weight were significantly lower in the congenital heart disease group (P=0.000).
Conclusion: Congenital heart disease is relatively prevalent in Iranian children with congenital hypothyroidism. We recommended cardiac evaluation for all hypothyroidism cases detected by the national screening program
Methods: In this cross- sectional descriptive study, 75 children with congenital hypothyroidism were evaluated by echocardiography using the census method. They had been detected during the national screening program of neonates; the diagnosis had been documented then. Patients with Down syndrome, low birth weight, and less than 1-month age were excluded from the study. Mean and standard deviations for quantitative variants and frequency for qualitative variants were applied. Student’s test- test, Pearson’s chi- square, and correlation index were used for data analysis.
Results: Congenital heart disease was detected in 20% of these hypothyroid children, including 12% atrial septal defect, 4% atrial and ventricular septal defects, and 4% mitral valve prolapse. Patent foramen ovale was detected in 21 children. No cardiac abnormality was reported in 52% of children. Gestational age and birth weight were significantly lower in the congenital heart disease group (P=0.000).
Conclusion: Congenital heart disease is relatively prevalent in Iranian children with congenital hypothyroidism. We recommended cardiac evaluation for all hypothyroidism cases detected by the national screening program
Keywords: congenital hypothyroidism, congenital heart disease, children, thyroid stimulating hormone (TSH)
Type of Study: Applicable |
Subject:
Pediatrics
Received: 2022/04/28 | Accepted: 2022/08/3 | Published: 2023/02/15
Received: 2022/04/28 | Accepted: 2022/08/3 | Published: 2023/02/15
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