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Department of Biology, Faculty of Basic Sciences, Hamedan Branch, Islamic Azad University, Hamedan, Iran , minoomahmoodi@yahoo.com
Abstract:   (83 Views)
Background and aim: Stem cells have a pivotal role in skin wounds healing; however, the mechanism of the healing effect of these cells is still not clear. The present study investigated the effect of foreskin derived fibroblast cells on diabetic wound healing and skin thickness and elasticity in male rats.
Materials and Methods: In this experimental laboratory study, fibroblast cells were isolated from the foreskin. 12 streptozotocin-induced diabetic male Wistar rats were divided into control (normal saline-treated) and fibroblast-treated rats. Wounds with a diameter of 0.8 cm were created by a biopsy puncture in the back of the mice. On days 7, 14 and 21, after treatment, the wound healing was evaluated by morphological observation, sonography and elasticity assesment. Data were analyzed using one-way analysis of variance.
Results: The healing rate and skin thickness and elasticity significantly increased in fibroblast cells treated group compared with control group. Skin gross elasticity (R2) and net elasticity (R5) of the skin in wound area had a significant increase on days 14 and 21 in the fibroblast injection group compared to the control group (P<0.05, P<0.01, P<0.001). On day 7, R5 and R7 had a significant increase (P<0.01).
Conclusion: The results of this study showed that foreskin derived fibroblast cells can accelerate diabetic wound healing by increasing the skin thickness and elasticity.
     
Type of Study: Original | Subject: Biology
Received: 2021/09/20 | Accepted: 2022/05/8

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