Volume 11, Issue 3 And 4 (March 1987)                   Research in Medicine 1987, 11(3 And 4): 122-131 | Back to browse issues page

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Rezaei Poor R. Generation and Evaluation of Monoclonal Autoantibodies in Systemic Lupus Erythematosis. Research in Medicine 1987; 11 (3 and 4) :122-131
URL: http://pejouhesh.sbmu.ac.ir/article-1-2538-en.html
Generation and Evaluation of Monoclonal Autoantibodies in Systemic Lupus Erythematosis
Robabeh Rezaei Poor
Department of Microbiology and Immunology, Faculty of Mecicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (1441 Views)
Three murine monoclonal anti-ssDNA autoantibodies have been produced by fusion of spleen cells from NZB/NZW F1 hybrid mice with Sp2/0-Ag 14 murine myeloma cells. Specificity studies characterizing monoclonal anti - ssDNA autoantibodies revealed binding patterns for nucleotides. Clone E-4-1 showed preferential binding with mono-di-and polyguanosine. Clones E-4-4 and E-11-1 specitically bound mono-di-and polythymidine. Results of inhibition studies indicated an order of reactivity for each monoclonal autoantiby; polynucleotide) dinucleotide) mononucleotide. 
Keywords: Autoantibodies, Lupus, Monoclonal
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Type of Study: Review | Subject: Interdisciplinary (Educational Management, Educational research, Statistics, Medical education
Received: 1986/11/27 | Accepted: 1987/06/10 | Published: 1987/12/4
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